Clinical Trial: Treatment of Cushing's Disease With R-roscovitine

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional




Official Title: Treatment of Pituitary Cushing Disease With a Selective CDK Inhibitor, R-roscovitine

Brief Summary: The investigators hypothesize that R-roscovitine will suppress pituitary corticotroph tumor ACTH production and normalize urinary free cortisol levels in patients with Cushing disease. To date, R-roscovitine has been evaluated in several Phase I and II studies and has shown early signs of anti-cancer activity in approximately 240 patients.