What is Ablavar?

ABLAVAR (gadofosveset trisodium) Injection is a sterile, nonpyrogenic, formulation of a stable gadolinium diethylenetriaminepentaacetic acid (GdDTPA) chelate derivative with a diphenylcyclohexylphosphate group. Each mL of ABLAVAR Injection contains 244 mg of gadofosveset trisodium (0.25 mmol), 0.268 mg of fosveset, and water for injection. It contains no preservative and the solution pH ranges between 6.5 and 8.0. Gadofosveset trisodium is chemically trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl]diethylenetriaminepentaacetato)(aquo) gadolinium(III),with a molecular weight of 975.88 g/mol, and an empirical formula of C33H40GdN3Na3O15P. It has a structural formula: Pertinent physiochemical data of ABLAVAR (gadofosveset trisodium injection) Injection are provided below: Table 3: Physiochemical Characteristics
Parameter Condition Value Osmolality (mOsmol/kg water) @ 37° C 825 Viscosity (cP) @ 20° C 3.0 Density (g/mL) @ 25° C 1.1224

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