Clinical Trial: Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: A Multicenter Observational Study to Evaluate Dynamics of Endothelin and Markers of Cellular Apoptosis in Cerebrospinal Fluid and Plasma in Moderate and Severe Human Head Injury
Brief Summary:
The goal of this study is to answer the following questions:
- What is the time course of the expected changes in endothelin levels during the first two weeks after injury and how does this relate to outcome?
- What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and type of injury, from CT scans and GCS?
- What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and outcome measurements like GOSE, ICP and CT scans?
- What is the relation between neurohormones related to the neutral endopeptidase (NEP) (ANP, BNP and cGMP) in plasma and cerebrospinal fluid and type of injury, from CT scans and GCS?
- What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and markers for apoptosis?
