Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL
Official Title: IMCY-NMO-000 In Vitro Study of the Biological and Immunological Activity of Imotopes� Candidates on Blood Cells of Patients With Stabilized Neuromyelitis Optica (PHASE 0)
Brief Summary:
This is a fundamental, prospective, multi-centres, interventional non-comparative study without the administration of a study product to patients.
A phase 0 study is particularly well adapted to early exploration of potential targeted treatments - i.e. treatments whose efficacy can only be hoped for in patients presenting specific biological characteristics in addition to being diagnosed with the targeted disease, Neuromyelitis Optica Spectrum Disorders (NMOSD) in this study.
The main goal of the study will be to support the selection of Imotopes� (i.e.
synthetic peptides encompassing HLA Class II T epitopes flanked by a thioreductase motif), and (i) capable of binding with class II HLA antigens of each patient and (ii) causing ex vivo the appearance of epitope -specific cytolytic CD4+ T cells.