Clinical Trial: An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional



Official Title: A Randomized, Double-Blind, Phase 2, Placebo Controlled, 2 Arm Study To Evaluate Dupilumab In Patients With Bilateral Nasal Polyposis And Chronic Symptoms Of Sinusitis

Brief Summary:

Primary Objective:

To evaluate the efficacy of dupilumab (SAR231893 / REGN668) in the treatment of bilateral Nasal Polyposis (NP) by assessment of the endoscopic nasal polyp score in comparison to placebo.

Secondary Objectives:

To evaluate effect of dupilumab with regards to:

  • symptoms of sinusitis
  • sinus Computed Tomography (CT) scan
  • nasal polyp score in the sub-group of patients with co-morbid asthma
  • Safety and tolerability