Clinical Trial: The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional



Official Title: The Relationship Between Saliva β-endorphins Levels, Sensitivity and Tolerance to Cold Pain and Perception of Pain in Oral Surgery Procedures in Adult Patients

Brief Summary:

The purpose of this study is to evaluate the correlation between β-endorphin levels in blood plasma and saliva in healthy participants with different pain sensitivity and in those with acute pain in oral and maxillofacial region.

Expected results

  • Relation between blood plasma and saliva β-endorphins levels
  • Differences of blood plasma β-endorphins levels in healthy participants with different pain sensitivity and in those with acute pain
  • Differences of saliva β-endorphins levels in healthy participants with different pain sensitivity and in those with acute pain
  • Objective method of patient's pain sensation evaluation
  • Correlation between patient's self-reported understanding of pain levels in oral surgery procedures, levels in saliva and blood plasma β-endorphins levels and sensitivity to cold test results

Study protocol:

Selection of participants

  1. Evaluation of pain perception in oral surgery procedures by healthy adult participants.
  2. Groups formation, according to the results from first stage, resulting in high and low pain rating participants groups.
  3. Control group formation from patients with acute pain in oral and maxillofacial region Control rating of participants

1. Patients that have been assigned to groups according to subjective pain ratings in oral surgery procedures will have to repeat the same questionnaire to e