How is primary ovarian insufficiency diagnosed?

If your periods become irregular or stop, your doctor will give you a physical exam and ask you questions about your general health and whether you have other symptoms of primary ovarian insufficiency. You will also have a pregnancy test. And your blood will be tested for other possible causes of irregular periods.

Source: http://www.webmd.com

What causes primary ovarian insufficiency?

Although the exact cause of primary ovarian insufficiency may be unknown, a genetic factor or a problem with the body's immune system may play a role in some women. In an immune system disorder, the body may attack its own tissues—in this case, the ovaries.

Primary ovarian insufficiency may develop after a hysterectomy or other pelvic surgery or from radiation or chemotherapy treatment for cancer. In some of these cases, the condition may be temporary, with the ovaries starting to work again some years later.

Source: http://www.webmd.com